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Liu F, Li JY, Han CB, Wang JH, Tong SY, Wang XK, Li YT, Sun WJ (2023) First cocrystal of esculetin: simultaneously optimized in vitro/vivo properties and antioxidant effect

doi: 10.1111/dom.13017 142 WrmeyerLNortmannOHamacherAUhlemeyerCBelgardtBEberhardDet al

The effect was due to on-target inhibition of GPX4 rather than reduction of GSH levels, as, contrary to the marked reduction in GSH observed with L-buthionine-sulfoximine (BSO), we observed only a small reduction with SCLA2 at 10 M and no change at 1 M (Extended Data Fig