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While GLP-1 therapies can help reduce appetite and improve metabolic control, they are most effective when combined with healthy eating, regular physical activity, and ongoing behavioral support
One of the most promising interventions is dietary restriction (DR) of either calories in general or specific macronutrients, as it consistently has been shown to prolong life- and healthspan in a broad range of model organisms and possibly humans, too, when compared with unrestricted food intake
Tretinoin causes retinoid dermatitis (redness, peeling, dryness) in most new users
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