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Regarding safety, the GLP-1 receptor agonists group reported a higher frequency of all adverse events, significantly in dyspepsia, vomiting, and constipation, with non-significant differences in diarrhea, headache, and fatigue
A 2022 analysis in JAMA Internal Medicine , for example, found that the use of GLP-1 RAs was associated with an increased risk for gallbladder or biliary diseases, especially when used at higher doses, for longer durations, and for weight loss
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