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Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)
This is further supported by the lack of Bip upregulation, a hallmark feature of ER stress (Fig
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J Clin Endocrinol Metab 92:902910 Dagan Y, Abadi J, Lifschitz A, Laron Z (2001) Severe obstructive sleep apnoea syndrome in an adult patient with Laron syndrome
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