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FOXO4-DRI causes nuclear exclusion of active p53 and induces apoptosis in senescent TM3 Leydig cells

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Subsequent reperfusion triggers an abrupt overproduction of ROS, including hydrogen peroxide, superoxide anion, hydroxyl radical, singlet oxygen, hypochlorous acid, and nitric oxide 33 , amplifying oxidative stress and aggravating tissue injury

However, it is often available for research purposes and may be used under specific conditions