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GLP-2 attenuates LPS-induced inflammation in BV-2 cells by inhibiting ERK1/2, JNK1/2 and NF-kB signaling pathways

The popularity behind semaglutide injections for weight loss stems from their effectiveness

Mansoor MA, Berit Guttormsen A, Fiskerstrand T, Refsum H, Ueland PM, and Svardal AM (1993a)

Recent evidence showed that Tirzepatide (TZP), a new drug including both Glucagon Like Peptide 1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP) receptor agonism, is effective in subjects with type 2 diabetes (T2D), lowering body weight, fat mass and glycated hemoglobin (HbA 1c ) also in obese or overweight adults without T2D

If the results are not what you expect on one medication, switching from semaglutide to tirzepatide or vice versa might be worth seeing if it produces a better effect

Asking the right questions helps patients stay informed, set realistic expectations, and participate actively in their care