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Trends Mol Med (2021) 27(10):9314
The findings that blockade of GLP-1 signalling abolished metformin-induced suppression of hepatic glucose output in rodents [13], and markedly attenuated the effect of metformin in reducing the glycaemic response to a mixed meal in people with type 2 diabetes [14], attest to a major role for GLP-1 in mediating the glucose-lowering effect of metformin
Repeat imaging at 612 months helps assess treatment response, with clinically meaningful improvement defined as at least a 30% relative reduction in hepatic fat content
Castellano-Castillo, D., et al
In a study conducted by the University of Alabama at Birmingham, mice treated with semaglutide lost over 13% of their body weight but regained 14% after stopping the treatment
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