Based on the available research, I believe conservative dosing produces the best outcomes for most people
The fatty-diacid-containing side chain attached through Lys17 was not resolved in any of the three structures, and the structural description should therefore not be interpreted as an equally resolved representation of every residue throughout the full 39-amino-acid peptide and its entire lipidated appendage
Literature on this topic is too large to summarise comprehensively, but it suffices to say that GLP1R agonists are capable of increasing the activity of neurons that promote satiety, while simultaneously decreasing the activity of neurons that promote hunger
This is a major barrier for oral GHK-Cu, significantly reducing how much active peptide reaches systemic circulation
It promises to give a miracle white skin and reduces the appearance of fine lines
Trends Mol Med 27:895906 Kovarik JJ, Bileck A, Hagn G, Meier-Menches SM, Frey T, Kaempf A, Hollenstein M, Shoumariyeh T, Skos L, Reiter B, Gerner MC, Spannbauer A, Hasimbegovic E, Schmidl D, Garhofer G, Gyongyosi M, Schmetterer KG, Gerner C (2023) A multi-omics based anti-inflammatory immune signature characterizes long Covid-19 syndrome
