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This association does not prove causation, and randomized trials designed to test long-term cardiovascular outcomes from oral carnitine are lacking

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The goals of managing patients with CKD are to improve quality and duration of life

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2.1.3.4 Altered macrophage polarization (M1/M2 balance) Macrophages are plastic and can shift phenotypes depending on cues classically activated M1 are pro-inflammatory and microbicidal, whereas alternatively activated M2 are anti-inflammatory and involved in repair ( Figure 2 )