The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others
Science 275 , 16491652 (1997)
Peroxisome proliferator-activated receptor gamma activation induces cell cycle arrest via the p53-independent pathway in human anaplastic thyroid cancer cells
Phase 2 Trials: Type 2 Diabetes Another phase 2 trial, published in The Lancet on August 12, 2023, focused on retatrutides effects in 281 adults with T2D (HbA1c 7.010.5%, BMI 2550 kg/m)
Both results were paired with lifestyle changes like nutrition and activity
The surgeon then attaches this pouch directly to part of the small intestine called the Roux limb