These side effects are usually most noticeable during the first 2 months and improve significantly by weeks 6-8
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Common side effects include nausea, diarrhea, or constipation, which typically decrease as your body adjusts
According to CDC data, the share of adults with type 2 diabetes using GLP-1 injectables more than doubled rising 155 percent between 2018 and 2022 while overall spending on these medications climbed more than 500 percent between 2018 and 2023
Where semaglutide might take 12-14 weeks to reach peak appetite suppression, retatrutide achieves clinically significant appetite changes by week 8 at therapeutic doses, and continues deepening those effects well beyond the point where semaglutide typically plateaus