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Discussion An emerging literature indicates that activating central GLP-1Rs is sufficient to reduce cocaine-seeking behavior 8,14,18 , findings that support translational studies focused on re-purposing GLP-1R agonists to treat CUD 5,22

While not entirely preventable, you can minimize fatigue by ensuring adequate caloric and protein intake despite reduced appetite, staying well-hydrated, following a gradual dose escalation schedule, and maintaining regular moderate physical activity

Both medications contain glucagon-like peptide-1 (GLP-1) receptor agonists

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