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Metformin and GLP-1 medications target weight loss and glucose management through different biological pathways, making their combination a clinically sound strategy for many patients

Strong preclinical coverage: improved insulin sensitivity in aged and high-fat-fed mice (Lee et al., Cell Metabolism 2015) and roughly doubled treadmill running time in old mice (Reynolds et al., Nature Communications 2021)

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An updated meta-analysis of nine randomised controlled trials (RCTs), including 8,920 patients with HF and T2D, reported a 13% reduction in major adverse cardiovascular events in the GLP-1 RA compared with placebo arm

Symptoms of glutathione deficiency include anemia, metabolic acidosis (a buildup of too much acid in the body), frequent infections and problems with the brain such as seizures, impaired intellect, and loss of coordination

In two head-to-head comparisons, a small, transient mean increase in HR from baseline was observed with lixisenatide