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[1] [2] The American Diabetes Association (ADA) and the American College of Physicians (ACP) recommend metformin as the preferred initial pharmacologic agent for type 2 diabetes, alongside lifestyle modifications including diet and exercise

These are favorable odds for a relatively low-risk intervention, but they underscore that peptide therapy does not work for everyone

Healthcare providers should conduct a thorough evaluation of patients reporting muscle cramps on GLP-1 therapy

Proc Natl Acad Sci U S A 108:1328113286

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