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This gradual dose escalation is designed to minimize common adverse effects, particularly gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation

Severe metabolic stress, prematurity, and some inborn errors of metabolism can also drive levels down

These include people with inherited metabolic disorders, severe malnutrition, kidney disease requiring dialysis, liver disease, or gastrointestinal conditions that reduce nutrient absorption

People with dry skin may need more hydrating products, while oily or acne-prone skin might benefit from lightweight formulas

It has been administered in senile dementia, metabolic nerve diseases, HIV infection, tuberculosis, myopathies, cardiomyopathies, renal failure and anaemia, and has been included in baby foods and milk [31]

Prussick has a research interest in the impact of diet on psoriatic disease and metabolic health, first becoming interested after being involved in Dr