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This was predicted to stabilise the N-terminal -helix (5-18) of the peptide through formation of an intramolecular salt bridge, as observed in a crystal structure of CagriBB fused at the C-terminal end of maltose-binding protein (PDB:7BG0) 2

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Research in aged primates demonstrates that Epithalon administration significantly increases nighttime melatonin levels in senescent monkeys while showing minimal effects in young animals, indicating specific targeting of age-related dysfunction

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Smuck, M

Bioorganic & medicinal chemistry, 26 (10), 2700-2707