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One study showed that IL15 causes the expression of NKG2D in memory CD8 + T Cells in skin with vitiligo, triggering the production of IFN and TNF.89 Additionally, oxidative stress has been shown to induce IL15 transpresentation in keratinocytes, contributing to the activation of memory CD8 + T Cells through the activation of the JAK/STAT pathway (JAK1-STAT3 and JAK3-STAT5).90 Thus, blocking IL15 signaling seems to be promising in the search for new treatments

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