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identified two chemical compounds functional hits 1 (FH1) and functional proliferation hit 1 (FPH1) through high-throughput screen (Shan et al., 2013)

It also contributes to removing toxins from the body

The placental pursuit for an adequate oxidant balance between the mother and the fetus

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Under persistent ER stress, the blockage of PERK-mediated global translation leads to the activation of IRE1/XBP1 (x-box binding protein 1) and ATF6 pathways, which in turn promotes the expression of various ER chaperones and ERAD mechanical components to enhance protein folding capacity and degrade irreversibly damaged proteins (Sharma et al., 2021)

This overstimulation leads to the cell danger response, triggered when we encounter a threat that exceeds our cellular capacity for homeostasis