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8,129,343 was filed on March 20, 2006, and was granted on March 6, 2012

This very short action limited the initial enthusiasm for the possible usefulness of incretins for the treatment of T2DM, and in turn stimulated the development of both GLP1 agonists resistant to DPP-4, with a longer half-life and of DPP-4 inhibitors that prolong the half-life of native incretins

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Both use a gradual dose escalation to minimize GI side effects, sharing the same schedule through 1.0 mg before diverging

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