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Flavonoids, such as quercetin and kaempferol, reduce this proliferation by modulating miRNAs like miR-21 and miR-145, thereby inhibiting VSMC proliferation and preventing arterial stenosis ( Reduction of Vascular Inflammation: Flavonoids decrease vascular inflammation by suppressing the expression of pro-inflammatory miRNAs, such as miR-155, which reduces immune cell infiltration into atherosclerotic plaques ( 5 Preclinical and clinical evidence The modulation of microRNAs (miRNAs) by flavonoids within the context of cardiovascular disease (CVD) represents an emerging area of research, with growing evidence suggesting beneficial effects of flavonoids on cardiovascular health via miRNA regulation
For example, glutathione is required for transporting mercury away from the cells and brain
Global burden of cardiovascular diseases and risk factors, 19902019
Valproate-induced hyperammonemic encephalopathy enhanced by topiramate and phenobarbitone: a case report and an update
This connection likely stems from how glutathione interacts with the brain and nervous system
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