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Srensen MB, Rosenfalck AM, Hjgaard L, Ottesen B

Kalaany and Sabatini had shown in NOD-SCID (non-obese diabetic, severe combined immunodeficient) mice that xenografted tumors with constitutive activation of AKT by either gains in PIK3CA or loss of PTEN are resistant against CR, and insensitive to insulin and IGF-1 treatment in vitro

That does not automatically mean the peptide is useless, but it does mean the confidence level should remain cautious