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The pharmacokinetic enhancement attenuated the peak of drug exposure combining with less dependence on GLP-1mediated pharmacology, and avoided the gastrointestinal adverse reactions of selective GLP-1 receptor agonist
nucleus basalis of Meynert, central gray (especially medial), amygdala, spinal cord, the bed nuclei of the stria terminalis, the shell of the nucleus accumbens and the dorsal raphe nuclei
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