The trade-off was injection site reactions (small nodules) in some patients, since the microspheres reside under the skin for weeks
Nausea, vomiting, diarrhea, constipation, pancreatitis symptoms, gallbladder problems, and potential thyroid concerns are the main issues discussed in clinical literature
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For the extraction, methanol and internal standards were added, followed by incubation for 15 min at 30C on a thermal shaker (650 rpm, TS1 ThermoShaker, Biometra, Gttingen, Germany), centrifugation (21,000 x g, 10 min, 4C, Heraeus Fresco 21 Centrifuge, Thermo Scientific, Schwerte, Germany), evaporation, and centrifugation with methanol again
The systematic review found that cohorts receiving beta-glucans reported improvement in their mood states as well as amelioration of overall wellbeing 24
Both help with blood sugar control and appetite suppression but come with side effects like nausea and stomach discomfort
