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However, the CNS is exposed to many situations that can induce a cell and tissue damage associated with ROS production

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In fact, the body depends on it

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After a steepest descent minimization (5,000 steps), the systems were equilibrated in several steps ((1) 500-ps simulation with constant number of particles, volume and temperature, and with a time step of t = 0.5 fs

There are cumulating data on reduced GSH levels and the consequent increased susceptibility to oxidative stress in many human diseases, contributing to the onset and worsening of these conditions