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For example, UDCA a closely related bile acid has not improved disease histology in randomized controlled trials and is not recommended in treatment guidelines.33 While TUDCA shows promise in animal NAFLD models, human studies so far have not shown improvements in liver fat, and its role in treating NAFLD remains unproven

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This cytoprotective effect involves upregulation of antioxidant defense systems and stabilization of mitochondrial function, with Dihexa-treated cells maintaining healthier mitochondrial membrane potentials under stress conditions