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Dephosphorylation/activation of the PDC is ascribed to two Mg and Ca dependant genetically and biochemically distinct isoforms of pyruvate dehydrogenase phosphatase PDP heterodimeric (PDP1&PDP2), which are important regulators of PDC activity

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Pregnant, breastfeeding or trying to conceive: stop at least 2 months ahead, given the 159 195 h half-life