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Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics
Adults with obesity but without type 2 diabetes received either the maximum tolerated dose of tirzepatide or the maximum tolerated dose of semaglutide
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