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But what we wanted to understand is what theyre doing in the brain. More than Just an Appetite Suppressant GLP-1 drugs were originally developed to treat Type 2 diabetes by improving insulin response, and their weight-loss effects were initially considered a side benefit

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The only covariates with SMDs above the minimum threshold of 0.2 were inclusion year, diabetes duration, obesity, and previous use of DPP-4is, GLP-1 RAs, insulins, and sulfonylureas