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As supply began to normalize, FDA resolved the tirzepatide shortage in December 2024 and the semaglutide shortage in February 2025, and provided phased enforcement grace periods for compounders to wind down operations

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Within certain months there were high rates of switching from and switching to semaglutide labeled for T2D, potentially pertaining to geographic and timing variations in both usage and shortages

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Kiens, Skeletal muscle lipid metabolism in exercise and insulin resistance., in Physiol Rev, vol