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10.1002/dmrr.3173 Summary Keywords metformin, polycystic ovary syndrome, infertility, mechanism, drug therapy Citation Zeng W, Luo Y, Ou J, Gan D, Huang M, Tomlinson B and Jiang Y (2025) Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes