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However, there are significant gaps in our understanding, including determining optimal dosages for efficacy and safety, elucidating precise mechanisms of action, establishing clinical efficacy through more large-scale trials, developing personalized treatment approaches, and studying the longstanding effects of vitamin supplementation in cancer patients

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Furthermore, PX-12 regulates metastasis of colon cancer cells by diminishing the expression of vascular endothelial growth factor and attenuating hypoxia-inducible factor 1 subunit alpha (HIF1A) levels [227]

10.1017/cjn.2016.310 204 WillingerT

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