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Fritzer-Szekeres M, Blom HJ, Boers GHJ, Szekeres T, and Lubec B (1998)
Experimental protocols were set up with Seahorse XF Pro Controller software (Agilent), which allows easy assay protocol creation
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While this positions cagrilintide as slightly less potent in vitro than salmon calcitonin (sCT, pEC ~1112), its superior stability, reduced aggregation risk, and long acting pharmacokinetic profile make it far more practical for sustained receptor engagement in both animal models and clinical investigation
The bioavailability is likely lower than injectable forms, but the convenience of oral administration may offset this for some applications
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