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These developments underscore a broader trend where obesity medicines are evolving into whole-body therapies with implications across multiple disease states
J Med Food 8(1):2730
Yang and colleagues now report that semaglutide suppresses adipogenesis and promotes osteogenesis of Bone Marrow Mesenchymal Stem Cells (BMSCs) in a dose-dependent manner and also improved trabecular bone mass in osteoporotic mice, through mechanisms requiring HIF-2
Their influence on neuronal communication and brain homeostasis is largely exerted via gliotransmitters such as GABA, glutamate, D -serine, lactate, and ATP/adenosine, in addition to neurotrophic factors like proBDNF and BDNF
The tirzepatide in Zepbound mimics two hormones, GLP-1 and GIP
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