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This variability reflects individual biological differences and the research-stage nature of the compound

Bayless D, Singh J, Park BU, Sweetser S

Diabetes mellitus represents the most significant risk factor for peripheral neuropathy in the UK, with approximately 50% of people with long-standing diabetes eventually developing some degree of nerve damage, according to Diabetes UK

The likely effect of the variation identified here is that towards the end of a weekly dosing period, those reduction effects will wear off