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Table of contents The 30-second answer Why these two drugs pull in opposite directions The blood sugar problem in plain numbers Short course vs long course: how the rules change The absorption question (does Zepbound delay prednisone?) Side effect overlap and what gets worse A working protocol for a typical 5-day prednisone burst Long-term steroid users on Zepbound Red flags that mean call the provider Compounded tirzepatide and prednisone (same rules apply) FAQ Footer disclaimers Why these two drugs pull in opposite directions Zepbound's active ingredient, tirzepatide, is a dual GLP-1 and GIP receptor agonist