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Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]
L-carnitine is an endogenous naturally occurring compound that plays an essential role in the energy and fat metabolism of the cells
SLC7A11 inhibition results in GSH depletion, which downregulates GPX4 levels, thereby promoting cellular/subcellular membrane damage caused by LPOs [28]
The presence of obesity-related complications such as obstructive sleep apnea, metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), or cardiovascular disease may justify longer treatment duration given the health benefits of sustained weight loss
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