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Snapshot Proponents May help cleanse the bowels before medical procedures May relieve constipation Skeptics Most health claims are not backed by science The benefits from coffees active compounds are more effectively (and pleasantly) achieved by drinking it Used as part of fraudulent and expensive cancer therapies May cause digestive issues, bowel injuries, and electrolyte imbalances Use through History The first documented uses of coffee enemas for poisoning and post-operative care date back to the 19th century

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Some researchers compensate by adding an extra 0.1-0.2mL of bacteriostatic water during reconstitution, accepting a slightly lower concentration in exchange for more usable doses

GHK-Cu addresses each of these issues through specific biological mechanisms

Modified structure designed to reduce binding to IGF-binding proteins (IGFBPs) in vitro