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Fiber undergoes bacterial fermentation in the colon, producing short-chain fatty acids (SCFAs)particularly butyrate, propionate, and acetatewhich can stimulate L-cell GLP-1 secretion

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Engelman says

This varies by peptide type and your individual health situation

We did detect mild staining around the mouth and nose of one rat treated with 50 nmol/kg/day GEP44 and one additional rat when treated with a single 100 nmol/kg dose of GEP44

The compound was first characterised in early-1970s aged-liver research by Loren Pickart