Simultaneously, Novo Nordisks SELECT trial confirmed a 20% reduction in major adverse cardiac events with semaglutide, expanding prescriber confidence and unlocking reimbursement across high-risk populations
What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
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Storage Handling and storage guidance for laboratory stability
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Pre-marketing studies revealed an incidence of less than 1% of hemolysis and methemoglobinemia among 703 patients