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doi: 10.1016/j.physbeh.2006.06.019 104

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Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC

The various epithelial cells along the length of the renal tubular filtration systems have distinct functions that are dictated by the unique organization of their basolateral and apical membranes

Sixth, based on prior human studies, even much larger doses of l-theanine and caffeine appear to be safe even for long-term administration and likely to be tolerated by a majority 43,44