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doi: 10.3389/fimmu.2020.00827 64 Diaz-VivancosP.WolffT.MarkovicJ.PallardF
The peptide sequence Gly-His-Lys chelates a single Cu(II) ion through the histidine imidazole nitrogen and the deprotonated amide nitrogens of the backbone
A 1200 mg/day ibuprofen dose (20 mg/kg/day, assuming an average human weight of 60 kg), would correspond to a treatment of 246.9 mg/kg/day in mice using the dose translation equation (Human equivalent dose (HED) = Animal Dose (mg/kg) Animal Km (3 for mouse)/Human Km (37 for human) 16
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