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The primary question emerging from the extant evidence is: why did the pronounced neuroprotective effects observed in laboratory settings and the significant risk-reduction signals in population studies not translate into a therapeutic advantage for patients with early Alzheimers disease in the EVOKE trial
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GLP-1 agonists as weight-loss medications The use of GLP-1 medications to treat diabetes eventually revealed an additional metabolic benefit: weight loss
It is postulated that GLP-1 RAs activate the GLP-1 R and transactivate the epidermal growth factor receptor (EGFR) via metalloproteinases
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