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New England Journal of Medicine, 375(19), 18341844
They work by mimicking gut hormones that reduce appetite and slow gastric emptying, leading to lower caloric intake and sustained weight loss for most patients
Many tirzepatide users report feeling cold as they lose weight, which makes physiological sense since fat tissue provides insulation and generates metabolic heat
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Weight loss medication: Doctors can prescribe weight loss medications alongside lifestyle change recommendations
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