In an exploratory analysis of the results of the REWIND trial, a CVOT for dulaglutide (another once-weekly GLP-1RA), a highly significant reduction of 13%-14% was observed in the risk of substantive cognitive impairment, also after adjustment for baseline scores, age ,sex, ethnic origin or education [26]
Why that matters: cortisol and GLP-1 effectiveness are inversely linked, and perimenopausal estrogen decline dysregulates the HPA axis, raising baseline cortisol and driving hormonal belly fat redistribution that keeps women stuck at a normal BMI with real metabolic dysfunction
Sharp chest pain that gets worse when you breathe in
The medication arrived on time, exactly as promised
Li, H., Wang, D., Yuan, Y
Importantly, all those with a baseline HbA1c in the range 4247 mmol/mol compatible with non-diabetic hyperglycaemia saw a reduction of HbA1C below 42 mmol/mol at 3 months into the intervention