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Developer: Eli Lilly and Company | Administration in Trials: Once-weekly subcutaneous injection First successful Phase 3 trial (TRIUMPH-4, topline Dec 2025): Up to 28.7% average body weight loss at 68 weeks (highest dose) in adults with obesity/overweight and knee osteoarthritis

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Side Effects and Safety Comparison# Melanotan-2 Side Effects# MT-2's broad receptor profile produces a wider side effect spectrum: Nausea : Common and dose-dependent