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As good clinical practice, ensuring that thyroid function is adequately controlled with levothyroxine before initiating additional therapies is advisable

Rats were housed under a 12-hour light/dark cycle with unlimited access to food and water

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Thus, there is an urgency to develop medications that can help treat CUD

Green tea EGCG inhibits DNMTs leading to hypomethylation of the tumour suppressor gene promoters (e.g., p16, RAR) and re-expression of pro-apoptotic genes as well as it interferes with RTK signalling NF-B activation that are associated with inflammatory and proliferative signals (16)