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MR: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing original draft, Writing review & editing
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Intramuscular Injections Subcutaneous Injections Additional information Additional information Key Benefits of Each Compound Tirzepatide + L-Carnitine Supports appetite regulation & satiety Helps reduce cravings & food noise Supports metabolic wellness & body composition AOD-9604 Supports fat metabolism pathways Commonly utilized for body recomposition support Helps support lean muscle preservation during calorie deficits MOTS-C Supports mitochondrial energy production Helps improve metabolic efficiency & endurance Commonly utilized in cellular performance & longevity protocols Tesamorelin Supports visceral fat optimization Helps support recovery & growth hormone signaling Commonly utilized in advanced physique & metabolic protocols Why They Work Well Together This protocol combines: appetite & metabolic regulation fat metabolism support mitochondrial energy optimization recovery & body composition support Rather than focusing only on weight loss, the goal is creating a more complete metabolic optimization protocol that supports energy, recovery, performance, and healthier long-term body composition
For inclusion in the group with T2D and a history of ASCVD, individuals also required a diagnosis of ASCVD at any time pre-index, broadly defined using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CM codes (online Supplementary Table S1)
Aimed at researchers, it emphasizes preclinical findings and future therapeutic possibilities.
