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Prolyl-Fluoropyrrolidine Analogs A range of prolyl-fluoropyrrolidine derivatives was synthesized as DPP-4 inhibitors by Sharma et al

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This process entails the adhesion of the peripheral immune cells to endothelial cells, which facilitates their translocation across the blood-brain barrier, ultimately resulting in barrier disruption, cerebral edema, and brain injury, which indirectly promote the infiltration of peripheral immune cells (69)

Additionally, gender differences in hormonal balance and body composition may affect how well these medications work for individual patients

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