My Approach When Prescribing Here's my general framework not a rigid protocol, but a starting point for the conversation: I Tend to Start with Semaglutide When The patient has established cardiovascular disease (because of the SELECT trial data) Insurance covers semaglutide but not tirzepatide The patient has MASH/fatty liver disease Cost is the primary concern and semaglutide is more accessible I Tend to Start with Tirzepatide When Maximum weight loss is the primary goal The patient has type 2 diabetes (tirzepatide shows greater A1C reduction roughly 2.02.5% vs 1.02.0% for semaglutide) The patient has tried semaglutide with insufficient results Insurance covers both options equally Regardless of which medication we choose, I always emphasize that GLP-1 therapy is most effective when combined with nutritional counseling, physical activity, and behavioral support
Pharmacokinetics, safety and tolerability of oral semaglutide in subjects with renal impairment
In a Canadian study, Hg was detected in all samples of swordfish, tuna, marlin, and shark purchased from major supermarket outlets and fish retailers, with swordfish containing the greatest concentration (57)
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Hydration requirements Both semaglutide and creatine increase your need for adequate hydration, though for different reasons
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