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It decreases melanin production to a certain degree, which causes rough skin and applied skin pigments to alleviate over a few days or months
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Chronic inflammation and cytokines (especially IL-6 and IL-1) continuously stimulate the HPA axis, leading to cortisol hypersecretion (Di Petrillo et al., 2025)
The semaglutide versus tirzepatide side effects comparison shows that tirzepatide generally produces less nausea than pure GLP-1 agonists at equivalent weight loss levels
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